And unfortunately this isĪ fairly common problem. Structures to make them not work as well. And we can go into a lot more detail about how this happens,īut, just understand that having a lot of glucose in your blood can cause changes to these Means "a lot of glucose "in the blood." If we have hyperglycemiaįor a long period of time, that can lead to what's referred to as "eye, nerve, and kidney disease." Eye, nerve, and kidney disease. That's called "hyper," hyper meaning "a lot of," "glycemia." "Hyperglycemia," which just Higher than 120, then we end up having a condition This is sort of the range that I would consider to be the, um Now, the body likes to keep the amount of glucose in the blood toīe no lower than about 70 milligrams per deciliter,Īnd no higher than about 120 milligrams per deciliter. Will be represented in milligrams per deciliter. So let's say this axis represents time, so over time, we'll see some changes, and this axis over here, the Y axis, will represent the concentration So now let's take a lookĪt how these hormones regulate the amount of And thankfully, we have these two hormones to help regulate the amount Important to have enough glucose available for yourĮssential organs to use. M&Ms, in a single day! Now that's a lot of M&Ms. That I think you and I appreciate a little more,ġ20 grams of glucose comes out to be about 250 It comes out to be about 60 to 70% of all the Because, for example, the brain uses about 120 grams of glucose per day. That we have enough glucose available in the blood. You've heard of probably is called "insulin." Insulin regulates that storage of glucose, as we'll talk more about in a minute, and the other guy on the end of the rope, is a hormone called "glucagon." Glucagon regulates the release Hormones that control the availability of glucose So let's focus on that, and we'll do so by starting with glucose, which is the most basicįorm of carbohydrates. Now carbohydrates are one of the main currencies for energy, Your stomach, and your intestines, which can then be absorbed and sent elsewhere for use. Each of these things deliverĮnergy into your GI tract. Here, which you have a lot of in ice cream Or they can be absorbed in carbohydrates, or I'll just write "carbs" Or they can be absorbed as fats, so these are lipids, or fatty acids and so your greasy, fried food is pretty rich in fats. It can be absorbed as amino acids, so, things that make up proteins, so, you'd imagine meat would have a lot of amino acids. Energy enters our body when we eat food, and that food is then absorbed in three different forms. Hormone activates receptor, directly triggers cell response.Is just the flow of energy throughout the body. Perform entire task of transducing a signal within target cell. Upon leaving, they diffuse into target cells and typically bind to receptors in cytoplasm or nucleus. Outside cell, bind to transport proteins that keep them soluble in aqueous blood. Activation of protein kinase A by cAMP leads to activation of enzyme required for glycogen breakdown and inactivation of enzyme needed for glycogen synthesis- net result is liver releasing glucose into bloodstream, providing fuel to deal with stress Steroids (lipid-soluble)- have receptor inside cell nucleus and acts as a transcription factor (bind at regulatory regions- promoters and enhancers). Stressful situation, adrenal glands secrete epinephrine (adrenaline), when reaches the liver it binds to a G protein-coupled receptor in the plasma membrane, binding of hormone to receptor triggers a cascade involving cAMP as a second messenger. Bind to cell-surface receptors, inducing changes in cytoplasmic molecules and sometime altering gene transcription. Cannot diffuse through the plasm membrane. Secreted by exocytosis and travel freely in the bloodstream. Peptides (water-soluble)- receptor in plasma membrane, triggers signal transduction (signal does not enter the cell).
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Goost H, Wimmer M, Barg A, Kabir K, Valderrabano V, Burger C. Evaluation of the Syndesmotic-Only Fixation for Weber-C Ankle Fractures with Syndesmotic Injury. CURRENT Diagnosis & Treatment in Orthopedics, Fourth Edition. Musculoskeletal Eponyms: Who Are Those Guys? Radiographics. It was later modified and popularized by the Swiss orthopedic surgeon, Bernhard Georg Weber (1929-2002), in 1972 2. This classification was first described by the Belgian general surgeon, Robert Danis (1880-1962), in 1949. Usually associated with an injury to the medial side Weber C fractures can be further subclassified as 6Ĭ1: diaphyseal fracture of the fibula, simpleĬ2: diaphyseal fracture of the fibula, complexĪ fracture above the syndesmosis results from external rotation or abduction forces that also disrupt the joint Medial malleolus fracture or deltoid ligament injury often presentįracture may arise as proximally as the level of fibular neck and not visualized on ankle films, requiring knee or full-length tibia-fibula radiographs ( Maisonneuve fracture) Tibiofibular syndesmosis disruption with widening of the distal tibiofibular articulation Weber B fractures could be further subclassified as 9ī2: associated with a medial lesion (malleolus or ligament)ī3: associated with a medial lesion and fracture of posterolateral tibiaĪbove the level of the syndesmosis (suprasyndesmotic) Variable stability, dependent on the status of medial structures (malleolus/ deltoid ligament) and syndesmosis may require open reduction and internal fixation (ORIF) Tibiofibular syndesmosis usually intact, but widening of the distal tibiofibular joint (especially on stressed views) indicates syndesmotic injuryĭeltoid ligament may be torn, indicated by widening of the space between the medial malleolus and talar dome Usually stable if medial malleolus intact treat with CAM Walker or Moon Boot with crutches and weight bear as tolerated with them for 6 weeksĭistal extent at the level of the syndesmosis (trans-syndesmotic) may extend some distance proximally Below the level of the syndesmosis (infrasyndesmotic) Kevin Durant is also looking to leap up the all-time scoring leaderboard as he needs 518 points to pass Hakeem Olajuwon, Elvin Hayes and Moses Malone for the 10th-most points. This is a reasonable feat for the King to accomplish - last season he scored 1,590 points - and using James' career average in points per game (27.2), he could reach this milestone by his 49th game this season. This season he closes in on yet another record as he is 1,348 points away from scoring 40,000 points, which would stamp his name in the record books as the first player to hit the mark. James hit one of the biggest milestones in the NBA last season when he passed Kareem Abdul-Jabbar to become the all-time leading scorer. Harden, amid the drama with the Philadelphia 76ers, could also earn a significant career record as he's 220 3-pointers away from passing Ray Allen for second on the NBA's all-time 3-pointers list.įrom individual players etching their names into the record books, such as LeBron James and Russell Westbrook, to remembering iconic matchups and game-winning moments, here are the biggest milestones, streaks and anniversaries to look for in the 2023-2024 NBA season. Both All-Stars are also chasing milestones as Lillard, the Portland Trail Blazers' all-time leader in points and 3-pointers, is 169 assists away from topping the franchise record as well. You have reached a degraded version of because you're using an unsupported version of Internet Explorer.įor a complete experience, please upgrade or use a supported browserĢ023-24 NBA milestones, anniversaries for LeBron James, Nikola Jokic, Stephen Curry, moreĪs the NBA enters its 77th season and fans anticipate another exciting campaign, there's always an additional buzz surrounding the significant milestones and anniversaries that are set to unfold in 2023-24.įans and players wait for the Damian Lillard and James Harden trade requests to be resolved. *Mini blog posts are the only emails I’d ever send that are fairly long, because they provide lots of value. *Mini blog posts (emails that are written well enough to be a blog post on their own).Discounts and flash sales (use sparingly).Other people’s content you found relates to things your list cares about.New content you created (blog posts, videos, infographics, etc.).The first step is to figure out what you want to say or share. Now that you’ve got those tips in your back pocket, let’s write your first email newsletter! 1. Try to write at a seventh-grade reading level or lower (you can use Hemingway Editor to check your content’s reading level).ĥ steps for writing your first newsletter Use short sentences and simple, easy-to-read wording. Keep your emails no longer than 3 to 5 paragraphs. So do yourself and your readers a favor, and make your emails short and sweet. Nearly 3.4 million emails are sent every second. I already mentioned this in the first tip, but it’s worth mentioning again from another angle. The final tip before we dive into the nitty-gritty: Don’t tell your life story! A best practice is to set expectations in your welcome email to tell people how often you’ll be emailing them. That said, you should always test different frequencies to see what works best for you. “Note: Campaigns are defined as targeted, individual emails sent to a portion of a database - not an email blast to everyone.” It seems the sweet spot is between 16-30 emails per month (an email daily or every other day). Here’s what they found for impact on open rates for their customers: If you’re a statistics-driven person, note that a HubSpot study which shared open rate medians also looked at the median open and engagement rates based on the number of emails sent per month. Send emails daily or multiple times a day? That’s probably bad unless your subscribers knew what they were signing up for. Send weekly emails every Friday? Great! Send biweekly or monthly emails? Awesome. Find a schedule, and stick to it (within reason).ĭon’t send three emails one week, then none the next. This one’s easy! Don’t send so many emails you annoy your audience, but don’t be a ghost, either. When you have trust AND a great subject line? Boom! High open rates. On the flip side, if they don’t know you well but your subject lines pique their curiosity or touch on something they really want, they’ll also open. If your audience trusts you as a person (or as a brand) and they trust your emails are usually valuable to them, they’ll probably open your email regardless of the subject line. Interesting Subject Line + Audience Trust = Open Rates Using your name in the “From” address instead of a brand name.Building trust with your audience that your emails are worth reading.Luckily, you can improve that drastically by: In other words, only a fifth of your subscribers will open your email. Not great. MailChimp ran a study of their customers and found the average open rate across all industries on their platform is just 20.81%. Getting people to open your emails is half the battle. (Unless that’s why they opted in for, then give them what they want.)Īsk yourself: If I got this email, would I care? It’s hard to be objective, but try. They only care about how you can help THEM with THEIR life and problems.īy the same token, don’t only send ads to your list. Your audience doesn’t care about your life or your problems. I’m not saying this to be harsh - I’m saying it because it’s true. It’s a waste of my time.Īnd that’s still not the end of the email! (Sorry Jonathan, love your work, but this is just too much for me to read in my email.) This one should be obvious, but I get emails telling me someone’s life story or things I couldn’t care less about all the time. How to outsource your newsletter 4 tips on how to write a newsletterīefore we dive into the practical steps, here are the basics of what makes a great newsletter. Motor skills: Manipulating puppets can be a positive way to encourage movement and to practice gross and fine motor control.Music appreciation: Puppets can make music and creative movement more interesting and can teach children the words and movements to new songs.Confidence in reading and speaking: Children who are reluctant to speak or read out loud may be more willing to talk or read to a puppet.Emotional development: Puppets can support children emotionally by giving them a “friend” to talk to, or a way to talk to other children without having to speak directly.Children can also practice these skills by using puppets to interact with other children. Social skills: Puppets can increase children’s communication and social skills by providing structured opportunities to interact with the puppets.Benefits of using puppets in child care include the following: Using puppets in the child care curriculum is an enjoyable way to promote children’s learning of new skills and concepts. Puppets are a great way to engage the attention and imagination of children of all ages. Benefits of Using Puppets in a Child Care Setting Children of all ages can enjoy using puppets in child care. Child care providers can use puppets, whether they are purchased at the store or homemade, to enhance almost any area of the child care curriculum. Puppets provide a wide range of benefits for children in a child care setting. New Jersey, United States: John Wiley & Sons, 2009. New Jersey, United States: John Wiley & Sons, 2006. Sebastopol, California: O'Reilly Media, 2019. macOS Catalina: The Missing Manual: The Book That Should Have Been in the Box. Sebastopol, California: O'Reilly Media, 2007. Time Machine: Comparison ChartĬhambers, Mark L. CCC uses a different approach to mirror your system and data disks as they were when cloned. CCC, on the other hand, creates a clone of your entire hard drive and captures your files just at a moment in time as they are. It looks for any file, folder or setting changes, and if something has changed since the last backup, it gets backed up but with only what’s changed, not the whole thing. Time Machine quietly and automatically checks your Mac once every hour and creates hourly backups. – One major difference between the two backup solutions is how the backups actually work. It preserves all our valuable data on a bootable drive, making it easy to boot from your backup in case a disaster strikes. CCC, on the other hand, creates bootable backups and clones to keep a secure fast backup of your hard drive. The secondary hard drive can be an external hard disk, an external USB or Thunderbolt hard drive, or an internal hard disk. – Time Machine automatically creates a backup of your entire hard drive onto a secondary hard drive, making things easy to revert back in case something happens. You need to download the application from “/.” Backup Solution Carbon Copy Cloner, on the other hand, is a powerful third-party backup utility program for Mac users, owned and distributed by Bombich Software. Time Machine is a native backup utility program that comes pre-installed with every Apple computer and it’s probably the easiest feature of macOS that carries your data from one computer to another. – Both are great backup solutions to back up your personal data, including photos, videos, email, music, apps and documents. Difference between Carbon Copy Cloner and Time Machine Availability When your disk is full, it automatically deletes your oldest backup files to make space for the newest backups. So, Time Machine backs up all the hard drives on your Mac to the external drive, but at the same time, it also allows you to exclude specific drives and folders if you want from backing up. Even a partition on any of the drives will work. While Time Machine makes things exceptionally simple for you, it requires an empty hard drive connected to your system. It creates hourly backups and makes things easy to revert back in case something happens. The whole point of Time Machine is to have a backup of your entire hard drive somewhere safe. Designed to work with external hard disk drives, Time Machine is a native application that automatically backs up your personal data, including photos, videos, email, music, apps and documents. It’s a silent and probably the easiest feature of macOS that carries your data from one computer to another. Time Machine is a backup utility program that comes pre-installed with every macOS device. Instead, the Rams punted, and the 49ers put the game away after tight end Ross Dwelley pulled down a 56-yard catch that set up Kittle's touchdown. Los Angeles missed a golden opportunity to get back in the game when Tyler Higbee dropped a third-down pass that - had he made the catch - would have been a big play for the 49ers as there was no one within 10 yards of him. The 49ers had already built a 10-point lead, but the outcome was still in doubt when the Rams took possession with just over 12 minutes left. Kupp suffered an apparent injury late in the game, with Sean McVay saying he regretted leaving the star receiver in the game at the end. Allen Robinson II played well (he caught five passes for the second straight game), but he alone wasn't enough to offset the Rams' lack of a running game and a third receiving option. The Rams couldn't run the ball, which put Stafford into too many predictable passing situations. The real story for the Rams was their continued lack of offensive rhythm. They also struggled to contain Aiyuk, who reached the 80-yard receiving barrier for a third straight game. Los Angeles' defense couldn't stop McCaffrey. McCaffrey is helping 49ers general manager John Lynch's case as this year's NFL Executive of the Year. He ran for 94 yards on 18 carries, caught eight passes for 55 yards and threw his second career touchdown pass. Why the 49ers wonĭespite sharing a field with reigning Super Bowl MVP Cooper Kupp, McCaffrey was the difference-maker in this game. Here's a closer look at what transpired in Inglewood. The 49ers responded with a 29-yard field goal by Robbie Gould after the Rams defense stiffened in the red zone. Los Angeles regained the lead minutes later when Stafford hit Cooper Kupp for a 17-yard score. San Francisco countered moments later when McCaffrey threw a touchdown pass Aiyuk, who led the 49ers with 81 yards on six receptions. The Rams struck first when Matthew Stafford's 1-yard touchdown run capped off a 17-play drive that took over nine minutes off the clock. After his short touchdown run stretched San Francisco's lead at the start of the fourth quarter, Garoppolo's 7-yard touchdown pass to George Kittle on the 49ers' next drive sealed San Francisco's eighth consecutive regular-season win over its division rival. McCaffrey made a nifty 9-yard touchdown catch from Jimmy Garoppolo with 1:51 left in the third quarter that gave the 49ers the lead for good. The visiting 49ers scored 24 unanswered points after trailing 14-7 midway through the second quarter. McCaffrey's effort was critical given that the 49ers played without All-Pro wideout Deebo Samuel, who is dealing with a hamstring injury. The former All-Pro amassed 149 total yards on 24 touches, not including his 34-yard touchdown pass to Brandon Aiyuk that got the 49ers on the board. McCaffrey joins Hall of Fame running backs Walter Payton and LaDainian Tomlinson and wide receiver David Patten in the history books as the only players to pull off the hat trick since the merger. The former All-Pro running back became the first 49ers player - and just the fourth since the 1970 merger - to throw, catch and run for touchdowns while leading his team to a 31-14 win over the Rams. In just his second game in a 49ers uniform, Christian McCaffrey did something that had previously never been done in the franchise's 76-year history. She got harder and faster until her body was literally slapping against my ass to the point I thought I was going to cum with no hands. She then used her legs to push my legs apart and fuck me deeper, all whilst kissing the back of my neck and moaning in my ear. She worked her way in deeper and deeper until she could feel I was able to take her fully. I was moaning away and she didn’t tell me to be quiet. She then eased herself in slowly, allowing me to get used to her size. She then pushed my body flat against the bed and teased her cock around my ass, running it up and down my ass hole to make sure the lube was rubbed all over. You could tell she really knew what she was doing. I was bent over on the bed in front of her while she put on a condom, and expertly allowed her lube to drip right into my ass hole. She was playing with my ass while I sucked her and then she got up implying she couldn’t wait any longer to fuck me. She even made gestures/noises as if she was about to cum which was such a turn on. She then laid down on the bed and I continued to suck her cock while she ran her fingers through my hair and told me how good it felt. It was way too big to fit it all in my mouth due to the girth but I gave it my best shot. I started sucking it and she instantly started moaning, her hygiene was impeccable. I dropped to my knees and she pulled out her extremely impressive cock, it looked amazing. My hand then made its way down to her bulge which was growing by the second. She’s extremely sensual/passionate which I love. I turned around and we started heavy DFK, which was such a turn on. I asked if I could take a quick shower and she provided me with a clean towel, whilst making light conversation to put me at ease (once again, her English is really good.) I returned to the bedroom and as I was putting down my things she immediately started kissing the back of my neck while her hands reached around my body. When I arrived at the apartment Carla greeted me at the door in sexy lingerie and walked me through to the bedroom. For me it was the perfect ratio of length/girth.Īs for the meet, as I said, it was incredible. It’s not the longest I’ve ever seen but very girthy. She has a great body with an absolute weapon of a cock. When she took them off she was still a good few inches taller than me. I was quite surprised at how tall she is! I’m 5’10 and with heels on she towered above me. It’s in a really nice area of London (Belgravia.) She told me she shares the flat with another TS SP, Roberts Cortes, however I didn’t see her during the session.Ĭarla looks exactly the same as her pictures/videos. The apartment was nice, albeit quite small. I didn’t try and negotiate her any lower. Her price is £300 for one hour, so she’s obviously on the pricey side, however considering how popular she is online I actually find that price quite a bargain. She was very patient with me in doing so also. I was a little sceptical that the ad was potentially fake/a scam since she’s quite well-known in the TS world, so I asked if she was able to verify herself which she did immediately. And she absolutely did not disappoint.Ĭomms were great, Carla replies instantly and her English is near enough perfect. I’ve been out of action for the past couple months, but when I saw Carla Brasil was in London I couldn’t pass up the opportunity to see her. Ok, right off the bat, this punt was incredible. Or if chemistry and attraction played a roll but definitely one of best sessions I've had.This is a review of a transsexual escort, so if that’s not your thing, don’t read! I don't know if her half hour is different from the hour. Was there about hour and 45min Id say but had to rush back to work. No problem in paying as long as the service matches. I've spent close to that in the past and been very disappointed. Came out kissed good by left an extra $100 on the way out. Exhausted layed there for a bit to re group. Back to 69 I came again jerking off while sucking her. Hurt and fell good at the same time but was a bit too much. Im more of top but was so caught up and horny decided what the hell. Spent a lot of time warming me up for that monster cock lol. Gave a light massaged with some chit chat. Definitely thought the session was over I was wrong. The layed on her back which was one of the best sights I saw when I was fuckking her. Nor counted it when I put it down) a+++ right there. Mutual oral in the shower and some more kissing. AND THEN! SHE HOPPED IN THE SHOWER WITH ME. Greeted at the door amazingly sexy words can't describe. She said I can shower there.Īrrived a few minutes early. I was at the gym told her I had to shower before I come by. Scheduled appointment via text straight forward. Plus, iMovie’s audio editing tools come with iMovie and work on your mobile devices. While not 100% automatic, for software that’s 100% free, we’re pretty impressed with this powerful tool.
A sequel, Expend4bles, was released on September 22, 2023. Partly due to negative critical reviews and being leaked three weeks before its scheduled release, the film grossed $214.7 million worldwide on an estimated $90–100 million budget, becoming the lowest-grossing film of the trilogy. Unlike the first two films in the franchise, The Expendables 3 received a PG-13 rating instead of an R rating, which upset many fans of the franchise. The film premiered in London on Aug and was released theatrically on August 15, 2014, by Lionsgate. The story follows the mercenary group known as The Expendables as they come into conflict with ruthless arms dealer Conrad Stonebanks, the Expendables' co-founder, who is determined to destroy the team. The film features an ensemble cast of largely action film stars including Sylvester Stallone, Jason Statham, Antonio Banderas, Jet Li, Wesley Snipes, Dolph Lundgren, Kelsey Grammer, Terry Crews, Randy Couture, Kellan Lutz, Ronda Rousey, Glen Powell, Victor Ortiz, Mel Gibson, Harrison Ford, and Arnold Schwarzenegger. It is the third installment in The Expendables franchise and the sequel to The Expendables (2010) and The Expendables 2 (2012). The Expendables 3 is a 2014 American action film directed by Patrick Hughes and written by Creighton Rothenberger, Katrin Benedikt and Sylvester Stallone. |
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